In patients requiring conventional oxygen support, giving a higher dose of dexamethasone raised risk for death compared with standard-dose corticosteroids. In patients hospitalized with COVID-19 who require oxygen support, dexamethasone (6 mg daily for 10 days) reduces mortality and is standard of care. Now, in a randomized open-label trial, the […]
Around 40% of patients with long COVID have moderate to severe sleep issues, according to new analysis of patients treated at Cleveland Clinic’s ReCOver Clinic. The report, published Tuesday in the journal of Internal Medicine, looked at the sleep patterns of 962 patients who had long COVID between February 2021 […]
The top recommended treatment for high-risk outpatients with COVID-19 in the NIH Guidelines is nirmatrelvir/r (Paxlovid). It’s quite clear why. In the EPIC-HR study, unvaccinated people at high risk for severe outcomes had an 89% reduction in the risk for hospitalization or death compared to placebo. If we just look at mortality — another important endpoint, […]
Question Does antiplatelet therapy administered to critically ill patients with COVID-19 improve organ support–free days (a composite end point of in-hospital mortality and duration of intensive care unit–based respiratory or cardiovascular support) up to day 21? Findings In this bayesian randomized clinical trial that included 1557 patients, antiplatelet therapy with either aspirin […]
Thousands more vulnerable people are eligible to receive the UK’s second antiviral Paxlovid, which has been added to the PANORAMIC national study. Paxlovid reduced the risk of hospitalisation or death by 88% in clinical trials and is already available directly through the NHS to highest-risk patients The UK has procured […]
Purpose:We assessed long‑term outcomes of dexamethasone 12 mg versus 6 mg given daily for up to 10 days in patients with coronavirus disease 2019 (COVID‑19) and severe hypoxaemia.Methods:We assessed 180‑day mortality and health‑related quality of life (HRQoL) using EuroQoL (EQ)‑5D‑5L index values and EQ visual analogue scale (VAS) in the […]
The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear. METHODS We conducted a double-blind, randomized, placebo-controlled, adaptive platform trial involving symptomatic SARS-CoV-2–positive adults […]
The timing of treatment in relation to vaccination is the strongest predictor of COVID-19 vaccine antibody response say the researchers of a new study. For their study, published in Nature Cancer, researchers from the University of Southampton led a UK multicentre prospective observational study (PROSECO) evaluating COVID-19 vaccine responses in individuals with […]
An analysis of data from nearly 154 000 US veterans with SARS-CoV-2 infection provides a grim preliminary answer to the question: What are COVID-19’s long-term cardiovascular outcomes? The study, published in Nature Medicine by researchers at the Veterans Affairs (VA) St Louis Health Care System, found that in the year after recovering from the illness’s […]
COVID-19 patients who are successfully weaned off a ventilator may take days, or even weeks, to regain consciousness, especially those who experienced episodes of hypoxemia while intubated, a new study shows. “As we started to see the first patients waking up after successful COVID-19 ICU treatments, we also encountered many […]
