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For Hospitalized Patients with COVID-19 Pneumonia, Tofacitinib May Be Beneficial

Compared with placebo, this Janus kinase inhibitor was associated with lower risk for death or respiratory failure in such patients. In patients hospitalized with COVID-19, excess inflammation generally underlies clinical progression. By reducing cytokine production, Janus kinase (Jak) inhibitors tamp down inflammation. Now, investigators report results of an industry-supported trial […]

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Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients

Background and Purpose: Reports indicate an increased risk of ischemic stroke during coronavirus disease 2019 (COVID-19) infection. We aimed to identify patients with COVID-19 and ischemic stroke and explore markers of inflammation, hypercoagulability, and endotheliopathy, a structural and functional disturbance of the vascular endothelium due to a stressor. Methods: This […]

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