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What is Sepsis?

Anyone can get an infection, and almost any infection, including COVID-19, can lead to sepsis. In a typical year: At least 1.7 million adults in America develop sepsis. At least 350,000 adults who develop sepsis die during their hospitalization or are discharged to hospice. 1 in 3 people who dies in a hospital had sepsis […]

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Preventive Medication for COVID-19 Infection

Tixagevimab-cilgavimab is a combination medication to help prevent COVID-19 infection. Tixagevimab-cilgavimab (Evusheld) consists of 2 long-acting monoclonal antibodies that bind to the spike protein of the virus that causes COVID-19 to prevent it from infecting human cells. When Can Tixagevimab-Cilgavimab Be Given? Tixagevimab-cilgavimab is not a treatment for COVID-19 and […]

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Treatment of Clostridioides difficile Infection

Guideline title ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections Release date May 18, 2021 Prior version 2013 Developer American College of Gastroenterology (ACG) Funding source ACG Target population Adults with suspected or diagnosed Clostridioides difficile infection (CDI) Major recommendations Initial CDI should be treated with vancomycin or fidaxomicin (strong recommendation; moderate-quality evidence). Metronidazole may be considered […]

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Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection

Monkeypox is a zoonotic orthopoxvirus in the same genus as variola (the causative agent of smallpox).1 A recent global outbreak has led to more than more than 39 000 cases reported as of August 18, 2022.2 Monkeypox is typically self-limited with symptoms generally lasting between 2 and 4 weeks in prior outbreaks. Hospitalization […]

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Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection

The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.1,2 Recently, the Centers for Disease Control and Prevention recommended shortening the strict isolation period for infected persons in non–health care settings from 10 days to 5 […]

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Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021

By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infection (nucleocapsid antibody or infection-induced seroprevalence) and from infection or vaccination (spike antibody or combined infection- and vaccine-induced seroprevalence). US seroprevalence from July 2020 to May 2021 based […]

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Optimizing Remdesivir’s Use for COVID-19: Infection vs. Inflammation

In a Spanish cohort study, adding remdesivir reduced mortality and progression to mechanical ventilation in hospitalized patients with high viral loads and low-grade inflammation. Initiating remdesivir within 5 to 7 days of developing COVID-19 symptoms maximizes this agent’s benefits by targeting the viral phase of illness before the onset of […]

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Researchers Find a Pathway to Prevent COVID Infection

The Catholic University of Louvain (UCLouvain) in Belgium announced that its researchers have managed to identify the key that allows the COVID-19 virus to attack cells. What’s more, they have succeeded in closing the lock to block the virus and prevent it from interacting with the cell, thereby preventing infection. […]

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