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Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection

The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.1,2 Recently, the Centers for Disease Control and Prevention recommended shortening the strict isolation period for infected persons in non–health care settings from 10 days to 5 […]

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Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021

By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infection (nucleocapsid antibody or infection-induced seroprevalence) and from infection or vaccination (spike antibody or combined infection- and vaccine-induced seroprevalence). US seroprevalence from July 2020 to May 2021 based […]

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Optimizing Remdesivir’s Use for COVID-19: Infection vs. Inflammation

In a Spanish cohort study, adding remdesivir reduced mortality and progression to mechanical ventilation in hospitalized patients with high viral loads and low-grade inflammation. Initiating remdesivir within 5 to 7 days of developing COVID-19 symptoms maximizes this agent’s benefits by targeting the viral phase of illness before the onset of […]

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Researchers Find a Pathway to Prevent COVID Infection

The Catholic University of Louvain (UCLouvain) in Belgium announced that its researchers have managed to identify the key that allows the COVID-19 virus to attack cells. What’s more, they have succeeded in closing the lock to block the virus and prevent it from interacting with the cell, thereby preventing infection. […]

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Nucleocapsid Antibodies Appear to Be Long-Lasting After SARS-CoV-2 Infection

In a prospective, longitudinal study, N-antibodies peaked 90–100 days after infection and persisted for at least 500 days in most patients. The duration of antibody response after SARS-CoV-2 infection is not clearly established, although prior studies have estimated that antibodies produced after natural infection last from 3 to 6 months. […]

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Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults

The incidence of the omicron BA.1/1.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rapidly spread worldwide even among vaccinated persons, is incompletely defined.1 We quantified the incidence of SARS-CoV-2 infection during the initial omicron BA.1/1.1 variant wave among Canadian adults2 and the contribution of previous infection and concurrent vaccination […]

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COVID-19 Infection Has More Than 50
Long-Term Effects

MADRID, Spain — Clinical experiences in approaching COVID-19 from different perspectives, results obtained by various therapeutic options and, above all, the challenges posed by a new healthcare reality — long COVID — were all the focus of a recent discussion at the 7th International Congress of the Spanish Society of Precision […]

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The Importance of Toxin Testing in C difficile Infection: Understanding the Results

Clostridioides difficile infection (CDI) is often confirmed through toxin testing, yet toxin tests alone may not be sufficient for diagnosing and guiding treatment decisions for patients with CDI. Dr David Lyerly “The presence of a toxigenic strain does not always equal disease,” said David Lyerly, PhD, during a session on C difficile toxin […]

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Omicron Sublineages Evade Immunity From Past Infection

A South African study based on blood samples found that the BA.4 and BA.5 sub-lineages of Omicron were more likely to evade antibodies produced by previous Omicron infections than the immunity provided by vaccinations. Scientists took blood samples from 39 people infected with Omicron, with 24 people not vaccinated and […]

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Cardiac Issues After COVID Infection and Vaccination: New Data

New data from two different sources on cardiac complications linked to COVID-19 have shown that such issues are low overall, but are higher after infection than after vaccination. The new information comes from the Centers for Disease Control and Prevention’s (CDC’s) National Patient-Centered Clinical Research Network (PCORnet), and from a separate […]

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