Medical Health Cluster


SARS-CoV-2 viral load and shedding kinetics

Abstract SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two key parameters for estimating infectiousness. As shedding of infectious virus is required for onward transmission, understanding shedding characteristics is relevant for public health interventions. Viral shedding is influenced by biological characteristics of the virus, […]

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Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans

Highlights Broad variation in neutralizing antibodies in SARS-CoV-2-convalescent individuals. ∼3% individuals showed a potent antibody response with SARS-CoV-1 cross-reactivity. Older age, symptomatic and severe disease predict higher SARS-CoV-2 neutralization. Serum and IgG neutralization half-lives were 14.7 and 31.4 weeks respectively. Summary Understanding antibody-based SARS-CoV-2 immunity is critical for overcoming the […]

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