SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Summary Background Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. Methods A large, multicentre, prospective cohort study was done, […]

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Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

The efficacy of two injections of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike messenger RNA (mRNA) vaccines (BNT162b2 [Pfizer] and mRNA-1273 [Moderna])1 in preventing symptomatic SARS-CoV-2 infection in persons without previous coronavirus disease 2019 (Covid-19) has been shown to be high. We wondered what the response would be to the […]

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COVID-19: Monoclonal Antibody / Anxiety & Depression / Helmet Ventilation vs. High-Flow Nasal Oxygen / Bamlanivimab & Variants

Monoclonal antibody treatment: GlaxoSmithKline and Vir Biotechnology are seeking emergency use authorization for their investigational monoclonal antibody treatment for early COVID-19. In an interim analysis of an efficacy trial of nearly 600 adults with COVID-19 who were at high risk for hospitalization, VIR-7831 was associated with an 85% lower risk […]

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