Medical Health Cluster

1 mayo, 2022

Factors Influencing COVID-19-Related Mortality Risk in T2DM Patients


  • Several factors are likely to influence the risk of subsequent COVID-19-related mortality in patients with type 2 diabetes mellitus (T2DM) following a confirmed COVID-19 infection.
  • The use of metformin, sodium-glucose co-transporter 2 inhibitors (SGLT2is), and glucagon-like peptide 1 (GLP-1) agonists and a non-smoking status were associated with a lower risk of COVID-19-related mortality in patients with T2DM.
  • Age, T2DM, male sex, and social disadvantage were linked to an increased risk of COVID-19-related mortality.

Why This Matters

  • The findings have led to a better understanding of the factors that put patients with T2DM at a higher risk of becoming seriously ill and dying following COVID-19 infection.

Study Design

  • A retrospective case-control study used data from the Greater Manchester Care Record (GMCR) database (2020-2021).
  • 13,807 patients with T2DM and subsequent confirmed COVID-19 infection (T2DM group) were matched (1:3) with 39,583 participants without T2DM and with confirmed COVID-19 infection (control group).
  • Funding: None.

Key Results

    • The COVID-19-related mortality rate was significantly higher in the T2DM vs control group (7.7% vs 6.0%; P<0.001).
    • In the T2DM group, the risk of COVID-19-related mortality was lower among (OR; 95% CI):
      • metformin users (0.494; 0.435 to 0.560);
      • SGLT2i users (0.299; 0.226 to 0.388);
      • GLP-1 agonist users (0.680; 0.464 to 0.960); and
      • non-smokers.
    • In the combined analysis of the T2DM and control groups, factors independently associated with a higher risk of COVID-19-related mortality were (adjusted OR; 95% CI):
      • T2DM (1.318; 1.159 to 1.498);
      • age (1.105; 1.099 to 1.112);
      • male sex (1.432; 1.267 to 1.621); and
      • social deprivation (higher Townsend score; 1.050; 1.032 to 1.068).


  • Retrospective design.

Créditos: Comité científico Covid

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