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14 junio, 2022

Constrictive Bronchiolitis — A Possible Adverse Effect of Vaping

Electronic cigarette or vaping–associated lung injury (EVALI) is a well-described, acute syndrome (NEJM JW Gen Med Jun 15 2020 and N Engl J Med 2020; 382:1589), but we know little about the long-term potential adverse effects of e-cigarette use. In this report, researchers describe four patients (age range, 25–65), with 3- to 8-year histories of e-cigarette use, who presented with symptoms consistent with gradually progressive pulmonary disease (e.g., dyspnea, cough, pleuritic chest pain). All patients were former smokers who vaped almost daily at presentation.

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Findings on pulmonary function testing were not strikingly abnormal, but on high-resolution computed tomography, all patients had mild bronchial wall thickening plus other nonspecific findings. Most interesting and important were the results of lung biopsy: All patients had constrictive bronchiolitis with subepithelial fibrosis (see Figure. opens in new tab). No patient had a history of other types of inhalation exposures or other diseases that are known to cause this pathologic finding; additionally, constrictive bronchiolitis is not known to result from cigarette smoking. Three of the patients stopped vaping and reported subjective improvement during several years of follow-up.

https://www.jwatch.org/na54968/2022/06/07/constrictive-bronchiolitis-possible-adverse-effect-vaping?ijkey=5PopvWi5F


Créditos: Comité científico Covid

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