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How Will the Pandemic Evolve After the Omicron Variant?

France — During a round-table discussion at the French Senate, specialists in infectious disease and epidemiology presented their thoughts on what might happen after the Omicron wave passes. Will COVID become an endemic disease, or will new, worrisome variants emerge? Using various types of data, the experts shared their views which, […]

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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

Abstract The newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hydrogen bonds formed by mutated residues R493, S496 and R498 in […]

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Omicron (B.1.1.529) – variant of concern – molecular profile and epidemiology: a mini review

Abstract Recently a new variant of SARS-CoV-2 was reported from South Africa. World Health Organization (WHO) named this mutant as a variant of concern – Omicron (B.1.1.529) on 26th November 2021. This variant exhibited more than thirty amino acid mutations in the spike protein. This mutation rate is exceeding the […]

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How Well Does COVID-19 Vaccination Protect Against the Delta Variant?

In a U.K. observational study, two doses of the Pfizer-BioNTech and Oxford/AstraZeneca vaccines had 88% and 67% effectiveness, respectively, against the Delta variant. As the Delta (B.1.617.2) SARS-CoV-2 variant fuels a global surge in COVID-19, an urgent clinical question concerns how effective the available vaccines are against this variant. Using […]

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Variant Proportions

Monitoring Variant Proportions Variants of SARS-CoV-2, the virus that causes COVID-19, are expected to continue to emerge. Some will emerge and disappear, and others will emerge and continue to spread and may replace previous variants. For example, the variant of the virus that caused the first U.S. COVID-19 cases in […]

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EU-Approved COVID-19 Vaccines Protect Against Delta Variant, Says Official

(Reuters) – Europe’s drug regulator said on Thursday the COVID-19 vaccines approved in the European Union offered protection against all coronavirus variants, including Delta, but called for active monitoring by vaccine manufacturers to stay alert. “There have been a number of variants over the last months and we expect more,” […]

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Pinpointing the Infectiousness of SARS-CoV-2 and Its Alpha (B.1.1.7) Variant

Asymptomatic infected individuals (and those infected with Alpha) had relatively high viral loads; samples from Alpha cases also had higher probability of viral culture positivity. Determining the infectiousness of individuals with COVID-19 requires considering degree of symptoms, time point within disease course, and whether the infection involves wild-type SARS-CoV-2 or […]

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