Off balance: Interferons in COVID-19 lung infections

Interferons are innate and adaptive cytokines involved in many biological responses, in particular, viral infections. With the final response the result of the balance of the different types of Interferons. Cytokine storms are physiological reactions observed in humans and animals in which the innate immune system causes an uncontrolled and […]

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Resurgence in SARS-CoV-2 Infections in HCWs Tied to Multiple Factors

Waning immunity to SARS-CoV-2 vaccination, coupled with the highly transmissible Delta variant and the end of mask mandates, likely contributed to a resurgence of SARS-CoV-2 infections among a highly vaccinated group of healthcare workers in California, according to a report released Wednesday. However, the “headline here needs to be nuanced,” […]

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Delta Variant Key to Breakthrough Infections in Vaccinated Israelis

Pfizer announced Thursday that it will seek US Food and Drug Administration (FDA) authorization for a booster shot of its COVID-19 vaccine as the company acknowledges its two-dose vaccine has shown waning effectiveness against the Delta variant. In a statement, the company said it will seek an emergency use authorization […]

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Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce

A 2-dose regimen of the BNT162b2 vaccine (Pfizer-BioNTech) against SARS-CoV-2 was authorized in December 2020 based on reported 94.8% efficacy.1 Although an association between vaccination and a reduction in symptomatic disease has been well described, an association with asymptomatic infection remains unclear.2,3 Methods In March 2020, St Jude Children’s Research Hospital […]

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